Multiple studies have shown that Lion’s Mane can boost the production of Nerve Growth Factor (NGF) in the brain — a protein essential for the growth and regeneration of nerve cells.

· In a 16-week human clinical trial, adults taking Lion’s Mane powder daily showed significant improvements in cognitive test scores compared to a placebo group [1].

· In vitro research shows that compounds unique to Lion’s Mane — hericenones and erinacines — can increase NGF production in nerve cells by up to 16% [2].

· Rich in beta-glucans and antioxidants, Lion’s Mane also helps reduce inflammation and protect overall brain health [3].

Lion’s Mane contains bioactive compounds that can cross the blood–brain barrier, directly stimulating nerve cells to produce more NGF. This promotes:

· Growth of new nerve fibers

· Repair of existing neural connections

· Enhanced memory, learning, and mental flexibility

All of this comes without the energy spikes and crashes associated with stimulants.

Chaga is one of the highest antioxidant-containing foods known, with an ORAC (Oxygen Radical Absorbance Capacity) score of over 146,000 — far exceeding blueberries (~4,600) or açai (~15,000) [1].

· research shows Chaga extracts can boost antioxidant enzyme activity by up to 30% and significantly reduce oxidative stress markers in cultured human cells [2].

· beta-glucans, Chaga helps modulate immune response and support healthy inflammation levels [3].

· 8 weeks improved antioxidant status and immune markers in healthy adults [4].

Chaga’s bioactive compounds work on two fronts:

     1. Beta-glucans help balance immune activity, enhancing defense against pathogens without overstimulating the system.

     2. Polyphenols and SOD protect cells from DNA damage and premature aging caused by free radicals.

The result: stronger immune resilience and improved cellular health.

Traditionally prized for vitality, Cordyceps sinensis now has human data showing it can improve aerobic capacity and energy metabolism.

· In a 6-week double-blind trial, 3 g/day of CS-4 increased VO₂ max by ~6.4% (1.88 → 2.00 L/min) while the placebo group saw no change. [1].

· A 12-week study reported +10.5% in metabolic threshold and +8.5% in ventilatory threshold. [2].

· In vitro research shows that Cordyceps sinensis extract can boost ATP production by ~68% in human cell cultures, and upregulate key sirtuins involved in energy metabolism — SirT1 by +33%, SirT3 by +10%, and SirT6 by +72% [3].

Cordyceps sinensis supports endurance and vitality by:

     1. Modest VO₂ max improvements suggest better oxygen uptake and delivery to muscles.

     2. Supports mitochondrial ATP production for sustained energy.

     3. Reduces oxidative stress and inflammation after exertion.

Long valued in Ayurveda as a stress tonic, Ashwagandha is now backed by modern trials for its cortisol-lowering and endurance-boosting effects.

·     In a meta-analysis of human trials, Ashwagandha supplementation improved VO₂ max by 4.09 mL/kg/min (≈ +9–10% in trained and untrained adults) compared to placebo [1].

· An 8-week randomized controlled trial (300 mg twice daily) increased VO₂ max by ~11%, while the placebo group showed no significant change [2].

· In a 60-day study with adults under chronic stress, 300 mg/day of standardized Ashwagandha extract reduced serum cortisol by 27.9% and perceived stress scores by 44% compared to placebo [3].

· Another double-blind trial found a 41% greater reduction in stress scores versus placebo after 60 days at 600 mg/day [4].

Ashwagandha’s withanolides help regulate the hypothalamic-pituitary-adrenal (HPA) axis, leading to lower cortisol levels and improved resilience to stress. Enhanced oxygen uptake (VO₂ max) supports physical performance and recovery.

Native to the Andes, maca has a growing body of research for stamina, mood, and sexual health benefits.

· In a 14-day double-blind trial with trained male cyclists, daily supplementation with 2 g of maca extract improved 40 km cycling time trial performance by ~1.1% compared to baseline, while the placebo group showed no change [1].

· The same study reported a ~10% improvement in sexual desire after 14 days [1].

· In a 12-week randomized controlled trial, maca supplementation (3 g/day) improved self-reported energy and well-being scores by ~20% compared to placebo [2].

· Rich in macamides and macaenes, maca root may also help maintain healthy mood and reduce mild anxiety and depression scores in menopausal women [3].

Maca’s bioactive macamides and macaenes are believed to support mitochondrial function and balance sex hormones, contributing to improved stamina, mood, and overall vitality.

Traditionally used in Russia and Scandinavia for endurance and mental clarity, Rhodiola has modern clinical backing for reducing fatigue and improving performance under stress.

· In a 4-week randomized, double-blind, placebo-controlled trial with physicians on night duty, 200 mg/day of standardized Rhodiola extract reduced fatigue scores by 20% and improved cognitive test accuracy by 9% compared to placebo [1].

· In a 12-week study with adults experiencing stress-related fatigue, Rhodiola supplementation improved fatigue symptoms by ~33% and reduced concentration difficulties by ~30% [2].

· A meta-analysis of 36 human trials found that Rhodiola supplementation significantly improved both mental and physical performance under fatigue-inducing conditions [3].

· Key active compounds, rosavins and salidroside, are linked to enhanced cellular energy production and reduced stress hormone release.

Rhodiola supports resilience by regulating stress-response pathways, improving mitochondrial efficiency, and increasing neurotransmitter activity related to focus and mood.

Sprouting multiplies the antioxidant potential of buckwheat, particularly its rutin and quercetin content.

· Sprouted buckwheat contains up to 30× more rutin than unsprouted seeds, enhancing its antioxidant potential [1].

· Human studies show rutin supplementation can improve vascular function and reduce markers of oxidative stress by 20–30% [2].

· Quercetin, also abundant in sprouted buckwheat, has been linked to reduced inflammation markers and improved exercise recovery in multiple human trials [3].

· In vitro research on sprouted buckwheat extracts shows significant inhibition of lipid peroxidation and free radical damage.

Rutin and quercetin act as potent antioxidants, protecting blood vessels, supporting healthy circulation, and helping the body manage oxidative stress.

Research shows cacao flavanols can improve vascular function and cerebral blood flow in as little as two hours.

· Daily flavanol-rich cacao (450–900 mg flavanols) improved endothelial function by ~23% in healthy adults.

· fMRI and flow studies show +10–14% cerebral blood flow within 2 hours of consumption.

· Theobromine offers gentle central nervous system stimulation, enhancing alertness without the jittery effects of caffeine.

Cacao flavanols enhance nitric oxide production, relaxing and widening blood vessels for better circulation. Magnesium supports muscle and nerve function, while theobromine provides a smooth, sustained lift in focus and mood.